Intradialytic Exercise Protocol in Patients with Chronic Kidney Disease: A Single Center Experience

Authors

DOI:

https://doi.org/10.71749/pkj.122

Keywords:

Exercise, Quality of Life, Renal Dialysis, Renal Insufficiency, Chronic

Abstract

Introduction: Chronic kidney disease (CKD) requires life-sustaining therapies such as hemodialysis (HD), which negatively affects patients' quality of life. Physical exercise has emerged as a promising, non-pharmacological strategy to mitigate these adverse effects.

Methods: This clinical study, conducted in Guarapuava, Brazil, included 41 HD patients who were divided into an intervention group (IG, n=28n=28 ) and a control group (CG, n=13n=13 ). Assessments were performed at baseline and after an eight- week intrarenalytic physical exercise program. The intervention consisted of stretching, resistance training (quadriceps, hip abductors/adductors, and ankle musculature), and aerobic activity (using a cycle ergometer). Exercises were individualized and monitored by measuring vital signs and applying the Borg Rating of Perceived Exertion Scale.

Results: Forty- one participants (28 IG, 13 CG) completed the protocol. The mean age was 56.5±10.2256.5±10.22 years, with hypertension and diabetes mellitus (DM) as the most prevalent comorbidities. Participants with DM had higher body mass index (BMI) and significantly lower dialysis adequacy (Kt/V). After intervention, the IG showed significant improvements in dialysis adequacy (from 1.27 to 1.42; p=0.004p=0.004 ), handgrip strength ( p=0.001p=0.001 ), and Barthel Index scores ( p=0.0021p=0.0021 ), reflecting greater independence in activities of daily living. Multivariate analysis (MANOVA) and Hedges' gg indicated moderate to large effect sizes, supporting the clinical relevance of these gains.

Conclusion: The findings indicate that intrarenalytic physical exercise yields clinically meaningful functional and physiological improvements, reinforcing its relevance as an effective adjunct to routine care for CKD patients undergoing hemodialysis.

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Published

17-05-2026

Data Availability Statement

The raw data have been organized in a secured spreadsheet and are available at the provided link (Caracterização Final -PKJ - ODJ 2025 .xlsx), protected by the password (95@SAvp39a4tJ8a), and will remain accessible until February 28, 2025. After this date, data access will require a formal written request submitted to the corresponding author or repository manager. If access is needed beyond the stated deadline, it must be formally requested through official communication and authorized by the study coordination team in accordance with institutional data-sharing policies.

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Intradialytic Exercise Protocol in Patients with Chronic Kidney Disease: A Single Center Experience. (2026). Portuguese Kidney Journal. https://doi.org/10.71749/pkj.122

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