Nephroprotective Effect of Panax Ginseng: A Systematic Review of Preclinical Studies in Animals
DOI:
https://doi.org/10.71749/pkj.72Keywords:
Acute Kidney Injury, Animals, Diabetic Nephropathies, Drug‑Related Side Effects and Adverse Reactions, Panax, Renal Insufficiency, ChronicAbstract
Introduction: Our objective was to shed light to the in vivo nephroprotective activity of Panax ginseng in animal models.Methodology: Systematic review in which the databases Medline (PubMed), Web of Science, Embase and Virtual Health Library were used to search for articles. The eligibility criteria were preclinical in vivo trials that evaluated the nephroprotective effect of P. ginseng by dosing biochemical markers in serum or urine.
Results: Forty‑five controlled pre‑clinical trials were included. Among the 16 studies that employed the animal model of diabetes kidney disease, 14 observed a nephroprotective effect of P. ginseng derivatives. All 30 studies employing animal models of kidney injury induced by drugs or nephrotoxic substances or caused by ischemia‑reperfusion found P. ginseng to have a nephroprotective effect.
Conclusion: The P. ginseng shows remarkable nephroprotective effects in different animal models of nephropathy. Therefore, its use is promising as an adjuvant in the treatment of diabetes kidney disease and prevention of drug‑induced nephropathy. Further randomized controlled clinical trials in humans are required to validate these findings.
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